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Natural Herbal combinations that increase telomere length.



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Telomere length is important if you want to live a long life.  The longer your telomeres, the longer you'll live. Patent Number: WO 2012106692

A1 filed in February of 2012 titled: Compound and method for increasing telomere length is the result of extensive testing by Isagenix for herbal combinations that increase telomere length. The main ingredients are Milk Thistle extract, Ashwagandha and Horny goat weed. The exact ratios in the combination were approximately 455 mg of activating ingredients and Vitamins C, E and B12 were added for stability. The activating ingredients were made up of 50% by weight and include milk thistle seed extract, and approximately a 25% combination of horny goat weed extract, grape seed extract, turmeric root extract, ashwagandha root extract, bacopa leaf extract, DL-alpha lipoic acid, N- acetyl-L-cysteine, pomegranate fruit extract and Asian ginseng root extract.


Another 25% of the formula consists of a combination of red raspberry fruit extract, green tea leaf extract, white tea leaf extract, black tea leaf extract, berberine rhizome extract, bilberry fruit extract, blueberry fruit extract, acacia bark extract, plantain leaf extract, L-glutathione, velvet bean extract, hawthorn root extract, quercetin, boswellia fruit extract, maca root extract, hawthorn fruit extract, resveratrol, harada fruit extract, shillajit extract, and chia seed extract. The dosage is three capsules (465 mg each) in the morning and three in the evening.


Although this may seem like a lot of complex ingredients, most companies will not state the full amount of ingredients in their formula due to competition.  An example is Astragalus from which the anti-aging substance TA-41 comes from. TA-41 is really an extract from Astragalus, which has been shown to act as a Telomerase activator. So we can see instead of using all the above ingredinets in the listed patent an extract of Astragalus works just fine.


This would explain the super boost I get from adding Astragalus tincture / extract to my carnosine formula called the Overnight RejuvenEssence formula. I used to use Astragalus powder, however I found that I achieved even better results from using an Astragalus tincture, probably because it contains the same extract that is in TA-41.

My revised 2016 book titled: Foods, Herbs and Pharmaceuticals that Extend Lifespan. A Summary Of Over 200 Research Studies Proven To Lengthen Lifespan has the final carnosine rejuvenessence formula.

 

 

Also a person known as "Josh" has been documenting his experiences with TA-41.



Stress shortens Telemores


Higher stress levels have been scientifically proven to cause accelerated shortening of telomeres. So it makes sense that herbs that reduce stress can prevent this from occurring. Herbs proven to lengthen telomeres include:



Milk Thistle


Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells. Thelen P, Wuttke W, Jarry H, Grzmil M, Ringert RH J Urol. 2004 May; 171(5):1934-8.



Green Tea


EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. Mittal A, Pate MS, Wylie RC, Tollefsbol TO, Katiyar SK. Int J Oncol. 2004 Mar; 24(3):703-10.



Ginseng


Biological Activities of Ginseng and Its Application to Human Health. Jae Joon Wee.



Resveratrol


Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro.


Lanzilli G, Fuggetta MP, Tricarico M, Cottarelli A, Serafino A, Falchetti R, Ravagnan G, Turriziani M, Adamo R, Franzese O, Bonmassar E. Int J Oncol. 2006 Mar; 28(3):641-8.


Genistein from soybeans


Genistein induces growth arrest and suppresses telomerase activity in brain tumor cells. Khaw AK, Yong JW, Kalthur G, Hande MP. October 2012.


Mistletoe


Mistletoe lectin induces apoptosis and telomerase inhibition. S.H. et al. Jan 2004.


Ginger


Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. W. Tuntiwechapikul et al. Dec 2010.



Curcumin


Mukherjee Nee Chakraborty S., Ghosh U., Bhattacharyya N.P., Bhattacharya R.K., Dey S., Roy M. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol. Cell. Biochem. 2007;297:31–39.

Singh M., Singh N. Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells. Mol. Cell. Biochem. 2009;325:107–119.

Cui S.X., Qu X.J., Xie Y.Y., Zhou L., Nakata M., Makuuchi M., Tang W. Curcumin inhibits telomerase activity in human cancer cell lines. Int. J. Mol. Med. 2006;18:227–231.

Chakraborty S., Ghosh U., Bhattacharyya N.P., Bhattacharya R.K., Roy M. Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. Mutat. Res. 2006;596:81–90.

Ramachandran C., Fonseca H.B., Jhabvala P., Escalon E.A., Melnick S.J. Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer Lett. 2002;184:1–6.



Horny Goat Weed (Epimedium)


Experimental study on effect of epimedium flavonoids in protecting telomere length of senescence cells.


So in conclusion, we can see that expensive patented supplments can be circumvented with just a little reserach.


 





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